Sean Wu Lab  

Sean Wu Lab

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Lab Overview

My research laboratory seeks to identify mechanisms responsible for human congenital heart disease, the most common cause of still-births in the U.S. and one of the major contributors to morbidity and mortality in infants and toddlers. We believe that by understanding the mechanisms regulating growth and differentiation of heart precursor cells during early embryonic development we can then apply these principles to understand the pathogenesis of adult onset heart diseases such as heart failure and arrhythmia where re-activation of early embryonic developmental program plays a central role. We currently use both genetically-modified mice as our living model to understand the biology of heart development as well as embryonic stem cells as a test-tube model to study the process of heart cell formation.


Recent News

NIH Pioneer Award LogoOctober 6th, 2014 - Congratulations to Dr. Sean M. Wu for receiving the 2014 NIH Director’s Pioneer Award. The NIH Director’s Pioneer Award, now in its 11th year, carries a five-year, $2.5 million direct cost research support plus indirect cost to be used in highly innovative approaches that have the potential to affect a broad area of biomedical or behavioral research. Sean's project titled “Enabling Technologies for Human-Machine Hybrid Tissue” will explore the use of 3D-printing to assemble complex array of interfaces between synthetic and biological materials. This technology could be applicable to generate hybrid tissues or artificial organs for future cardiovascular applications.
Circulation Research coverAugust 29th, 2014 - Congratulations to Arun Sharma, Ryoko Hamaguchi, Rajarajan Kuppusamy, and Anthony Sturzu whose paper on “Human induced pluripotent stem cell-derived cardiomyocytes as an in vitro model for coxsackievirus B3-induced myocarditis and antiviral drug screen platform” made the cover for this journal issue.
American Heart Association LogoAugust 4th, 2014 - Congratulations to Dr. Guang Li whose abstracts on "Identification Of Cardiovascular Lineage Descendants at Single Cell Resolution" and on "YY1 Expression is Sufficient for the Maintenance of Cardiac Progenitor Cell State" have been accepted for presentation at the annual Scientific Sessions of the American Heart Association.

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