Sean Wu Lab  

Sean Wu Lab

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Lab Overview

My research laboratory seeks to identify mechanisms responsible for human congenital heart disease, the most common cause of still-births in the U.S. and one of the major contributors to morbidity and mortality in infants and toddlers. We believe that by understanding the mechanisms regulating growth and differentiation of heart precursor cells during early embryonic development we can then apply these principles to understand the pathogenesis of adult onset heart diseases such as heart failure and arrhythmia where re-activation of early embryonic developmental program plays a central role. We currently use both genetically-modified mice as our living model to understand the biology of heart development as well as embryonic stem cells as a test-tube model to study the process of heart cell formation.

Recent News

NSF LogoApril 1, 2014 - Congratulations to Arun Sharma who has been awarded a 2014 National Science Foundation (NSF) Graduate Research Fellowship Program (GRFP) Fellowship. He was selected amongst a competitive pool of applicants based on his "outstanding abilities and accomplishments, as well as potential to contribute to strengthening the vitality of the US science and engineering enterprise." The GRFP Fellowship period is up to 5 years, with support provided for a maximum of three years starting in 2014.
March 27, 2014 - Congratulations to Arun Sharma who has successfully passed his PhD qualifying examination for his thesis work on cardiovascular disease modeling using human induced pluripotent stem cells.
Stem Cell Research & Therapy LogoDecember 24, 2014 – Congratulations to Arun Sharma whose paper on “Induced pluripotent stem cell-derived cardiomyocytes for cardiovascular disease modeling and drug screening” has been published in the journal Stem Cell Research and Therapy.
Stem Cells LogoFebruary 15, 2014 – Congratulations to Marc Engels, Arun Sharma, and Rajarajan Kuppusamy whose paper on “IGF promotes cardiac lineage induction in vitro by selective expansion of early mesoderm” has been published online in the journal Stem Cells.
CVI LogoFebruary 28, 2014 – Congratulations to Anthony Sturzu who has been award one of two Best Poster Award ($500) at the Stanford Cardiovascular Regenerative Medicine Symposium 2014.
JCPT LogoMarch 4, 2014 – Congratulations to Jenny Chen (former lab member) and Karolina Plonowska whose paper on “Somatic cell reprogramming into cardiovascular lineages” has been accepted for publication in the Journal of Cardiovascular Pharmacology and Therapy.

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