Sean Wu Lab  

Sean Wu Lab

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Lab Overview

My research laboratory seeks to identify mechanisms responsible for human congenital heart disease, the most common cause of still-births in the U.S. and one of the major contributors to morbidity and mortality in infants and toddlers. We believe that by understanding the mechanisms regulating growth and differentiation of heart precursor cells during early embryonic development we can then apply these principles to understand the pathogenesis of adult onset heart diseases such as heart failure and arrhythmia where re-activation of early embryonic developmental program plays a central role. We currently use both genetically-modified mice as our living model to understand the biology of heart development as well as embryonic stem cells as a test-tube model to study the process of heart cell formation.

Recent News

June 24th, 2014 - Dr. Sean M. Wu receives the 2014 David Lawrence Stein Award from the American Heart Association Western Region Affiliate. The David Lawrence Stein Research Award is given in recognition of outstanding achievement in pediatric research and is presented to the researcher whose grant the American Heart Association scores the highest among the hundreds it receives from the Western Region Affiliate for consideration each year. Dr. Wu’s grant, entitled, “Transcription Factor Interplay at the Nkx2.5 Cardiac Enhancer,” seeks to determine the key genes regulating cardiac development during mesodermal commitment into cardiac progenitor cells using both embryonic mice and mouse embryonic stem cells as models. The research support from the AHA will enable Dr. Wu to identify the critical transcription factors that drive the expression of Nkx2.5 and how these factors are regulated during embryonic development.
Circulation Research coverJune 3rd, 2014 - Dr. Sean Wu has been invited to join the editorial board of Circulation Research, a premiere basic cardiovascular research journal with an ISI impact factor of 11.86 (2012). Dr. Wu has been an active reviewer for the journal for the past six years and has published a number of primary, review, and editorial articles in this journal.
UCSF logo May 15, 2014 - Congratulations to Ms. Karolina Plonowska (Research Assistant) for being accepted to UCSF Medical School. We are particularly delighted that she will be very close by and be able to provide her expertise in CRISPR/Cas9 genome editing and manuscript submissions.
May 2, 2014 - Congratulations to Dr. Guang Li, a post-doctoral fellow in the Wu lab, for being awarded the NHLBI-funded Progenitor Cell Biology Consortium (PCBC) Jump Start Award proposal. His project title - “Identification of Cardiac Lineage-Defining Epigenome at Single Cell Resolution” - involves a collaboration with Dr. Lars Omberg at Sage BioNetwork to analyze epigenomic changes within individual cardiac progenitor cell during development.

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