Sean Wu Lab  

Sean Wu Lab

Sean Wu Lab home page image

donate to the
sean wu lab

Lab Overview

My research laboratory seeks to identify mechanisms responsible for human congenital heart disease, the most common cause of still-births in the U.S. and one of the major contributors to morbidity and mortality in infants and toddlers. We believe that by understanding the mechanisms regulating growth and differentiation of heart precursor cells during early embryonic development we can then apply these principles to understand the pathogenesis of adult onset heart diseases such as heart failure and arrhythmia where re-activation of early embryonic developmental program plays a central role. We currently use both genetically-modified mice as our living model to understand the biology of heart development as well as embryonic stem cells as a test-tube model to study the process of heart cell formation.

Recent News

Santa Monica Fertility logoAugust 10th, 2014 - Congratulations to senior post-doctoral fellow Dr. Kuppusamy Rajarajan who has been offered the position of Scientific Director at the Santa Monica Fertility Center in Santa Monica, CA. He has accepted this new position that involves managing a staff of scientists and nurses on reproductive biology work. He will start there on September 15th, 2014.
American Heart Association LogoAugust 4th, 2014 - Congratulations to Dr. Guang Li whose abstracts on "Identification Of Cardiovascular Lineage Descendants at Single Cell Resolution" and on "YY1 Expression is Sufficient for the Maintenance of Cardiac Progenitor Cell State" have been accepted for presentation at the annual Scientific Sessions of the American Heart Association.
Circulation Research coverJuly 2nd, 2014 - Congratulations to Mr. Arun Sharma, Ryoko Hamaguchi, Rajarajan Kuppusamy, and Anthony Sturzu whose paper on “Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes as an In Vitro Model for Coxsackievirus B3-Induced Myocarditis and Antiviral Drug Screening Platform” has been accepted for publication in Circulation Research.
June 24th, 2014 - Dr. Sean M. Wu receives the 2014 David Lawrence Stein Award from the American Heart Association Western Region Affiliate. The David Lawrence Stein Research Award is given in recognition of outstanding achievement in pediatric research and is presented to the researcher whose grant the American Heart Association scores the highest among the hundreds it receives from the Western Region Affiliate for consideration each year. Dr. Wu’s grant, entitled, “Transcription Factor Interplay at the Nkx2.5 Cardiac Enhancer,” seeks to determine the key genes regulating cardiac development during mesodermal commitment into cardiac progenitor cells using both embryonic mice and mouse embryonic stem cells as models. The research support from the AHA will enable Dr. Wu to identify the critical transcription factors that drive the expression of Nkx2.5 and how these factors are regulated during embryonic development.
Circulation Research coverJune 3rd, 2014 - Dr. Sean Wu has been invited to join the editorial board of Circulation Research, a premiere basic cardiovascular research journal with an ISI impact factor of 11.86 (2012). Dr. Wu has been an active reviewer for the journal for the past six years and has published a number of primary, review, and editorial articles in this journal.

Stanford Medicine Resources:

Footer Links: